Interactions between AAV-2 and HSV-1: implications for hybrid vector design
نویسندگان
چکیده
منابع مشابه
Modeling the synergy between HSV-2 and HIV and potential impact of HSV-2 therapy.
Mounting evidence indicates that genital HSV-2 infection may increase susceptibility to HIV infection and that co-infection may increase infectiousness. Accordingly, antiviral treatment of people with HSV-2 may mitigate the incidence of HIV in populations where both pathogens occur. To better understand the epidemiological synergy between HIV and HSV-2, we formulate a deterministic compartmenta...
متن کاملWorldwide circulation of HSV-2 × HSV-1 recombinant strains
Homo sapiens harbor two distinct, medically significant species of simplexviruses, herpes simplex virus (HSV)-1 and HSV-2, with estimated divergence 6-8 million years ago (MYA). Unexpectedly, we found that circulating HSV-2 strains can contain HSV-1 DNA segments in three distinct genes. Using over 150 genital swabs from North and South America and Africa, we detected recombinants worldwide. Com...
متن کاملProtection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs.
BACKGROUND A herpes simplex virus (HSV)-2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1-seronegative women but not in men or HSV-1-seropositive women. METHODS To determine the effect of HSV-1 serostatus on effectiveness of different vaccines, we tested gD2 in alum/MPL, gD2 in Freund's adjuvant, and dl5-29 ...
متن کاملPrevalence and risk factors of HSV-1 and HSV-2 antibodies in European HIV infected women.
OBJECTIVES To investigate the prevalence and risk factors of HSV-1 and HSV-2 antibodies in HIV infected women and the association between recurrent genital ulcerations and HIV disease progression in HSV-2 positive women. METHODS The presence of HSV antibodies was tested in 276 of the 487 women participating in a European cohort study of HIV infected women. Prevalence rate ratios described the...
متن کاملThe burden of infection with HSV-1 and HSV-2 in England and Wales: implications for the changing epidemiology of genital herpes.
OBJECTIVE To measure the burden of infection with herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2) in the general population of England and Wales and to assess temporal changes in the incidence of HSV-1 infection in childhood. METHODS 4930 residual blood samples taken from people aged 0-69 years and submitted to 15 public health laboratories in England and Wales between January...
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ژورنال
عنوان ژورنال: Future Virology
سال: 2011
ISSN: 1746-0794,1746-0808
DOI: 10.2217/fvl.11.13